It depends on the gauge of the steel studs. Lighter gauge steel studs will likely flex too much and may not provide a stable structure for the panels. Heavier gauge studs will provide the structure but may present difficulties with fastening and fasteners. In previous projects, some installers have solved these issues by installing wood blocking within the steel studs. This application has not been tested by PCS, so please proceed with caution until you are sure that the blocking provides the stable structure that Synthesis™ requires.